Drug interactions
Diltiazem + Fosaprepitant
Severity: Moderate
Diltiazem and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, whose levels may rise with diltiazem. Aprepitant is also a weak-to-moderate CYP3A4 inhibitor that may increase diltiazem exposure. Clinical effects are generally modest.
What this interaction means in plain words
Diltiazem and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of aprepitant, and aprepitant can inhibit CYP3A4 in return.
What to do
Single-dose fosaprepitant can usually be given. Monitor for aprepitant adverse effects and for hypotension or bradycardia from diltiazem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diltiazem and Fosaprepitant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Diltiazem with Fosaprepitant?
MediHelp rates the interaction as moderate. Diltiazem and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, whose levels may rise with diltiazem. Aprepitant is also a weak-to-moderate CYP3A4 inhibitor that may increase diltiazem exposure. Clinical effects are generally modest.
How serious is the interaction between Diltiazem and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Single-dose fosaprepitant can usually be given. Monitor for aprepitant adverse effects and for hypotension or bradycardia from diltiazem.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
