Drug interactions
Diltiazem + Iloperidone
Severity: Moderate
Diltiazem and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is partly metabolized by CYP3A4, so diltiazem can raise its levels, and both drugs may contribute to QT prolongation or bradycardia. Iloperidone may in turn modestly affect diltiazem levels.
What this interaction means in plain words
Diltiazem and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of iloperidone, with additive cardiac conduction effects.
What to do
Monitor ECG, especially QT interval, and heart rate. Consider reducing the iloperidone dose if QT prolongation or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Diltiazem with Iloperidone?
MediHelp rates the interaction as moderate. Diltiazem and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is partly metabolized by CYP3A4, so diltiazem can raise its levels, and both drugs may contribute to QT prolongation or bradycardia. Iloperidone may in turn modestly affect diltiazem levels.
How serious is the interaction between Diltiazem and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, especially QT interval, and heart rate. Consider reducing the iloperidone dose if QT prolongation or adverse effects occur.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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