Drug interactions
Diltiazem + Lasmiditan
Severity: Minor
Diltiazem and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-gp in vitro and may raise levels of P-gp substrates. Diltiazem is a P-gp substrate, but the effect is likely small. Both can slow heart rate.
What this interaction means in plain words
Diltiazem and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan may inhibit intestinal P-glycoprotein, increasing absorption of P-gp substrates.
What to do
No dose adjustment is routinely needed. Monitor heart rate if the two drugs are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Diltiazem with Lasmiditan?
MediHelp rates the interaction as minor. Diltiazem and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-gp in vitro and may raise levels of P-gp substrates. Diltiazem is a P-gp substrate, but the effect is likely small. Both can slow heart rate.
How serious is the interaction between Diltiazem and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor heart rate if the two drugs are used together.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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