Drug interactions
Diltiazem + Liposomal doxorubicin
Severity: Moderate
Diltiazem and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and P-glycoprotein and can raise doxorubicin exposure, with increased myelosuppression or cardiotoxicity. Diltiazem also has negative inotropic effects that may add to doxorubicin cardiac risk.
What this interaction means in plain words
Diltiazem and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Liposomal doxorubicin belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by diltiazem, plus additive negative inotropy.
What to do
Monitor blood counts and cardiac function. Consider a non-interacting antihypertensive or rate-control option where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Diltiazem and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and P-glycoprotein and can raise doxorubicin exposure, with increased myelosuppression or cardiotoxicity. Diltiazem also has negative inotropic effects that may add to doxorubicin cardiac risk.
How serious is the interaction between Diltiazem and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Consider a non-interacting antihypertensive or rate-control option where possible.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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