Drug interactions
Diltiazem + Lurasidone
Severity: Moderate
Diltiazem and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem increases lurasidone exposure, which may increase sedation, akathisia, parkinsonism and other adverse effects. Lurasidone relies mainly on CYP3A4 for clearance.
What this interaction means in plain words
Diltiazem and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Moderate CYP3A4 inhibition by diltiazem reduces lurasidone clearance.
What to do
Start lurasidone at 20 mg daily and do not exceed 80 mg daily during concurrent use. Monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Diltiazem with Lurasidone?
MediHelp rates the interaction as moderate. Diltiazem and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem increases lurasidone exposure, which may increase sedation, akathisia, parkinsonism and other adverse effects. Lurasidone relies mainly on CYP3A4 for clearance.
How serious is the interaction between Diltiazem and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lurasidone at 20 mg daily and do not exceed 80 mg daily during concurrent use. Monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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