Drug interactions
Diltiazem + Solifenacin
Severity: Moderate
Diltiazem and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and can raise solifenacin exposure, increasing anticholinergic adverse effects and potentially QT effects. The rise is usually modest and manageable.
What this interaction means in plain words
Diltiazem and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated solifenacin metabolism by diltiazem.
What to do
Monitor for anticholinergic effects and reduce solifenacin dose if they occur. Keep within the maximum dose recommended for use with CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Solifenacin?
MediHelp rates the interaction as moderate. Diltiazem and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor and can raise solifenacin exposure, increasing anticholinergic adverse effects and potentially QT effects. The rise is usually modest and manageable.
How serious is the interaction between Diltiazem and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce solifenacin dose if they occur. Keep within the maximum dose recommended for use with CYP3A4 inhibitors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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