Drug interactions
Diltiazem + Tipranavir
Severity: Moderate
Diltiazem and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 substrates and inhibitors, so combining them can raise concentrations of either one. Higher diltiazem exposure may cause bradycardia, AV block or hypotension, and tipranavir exposure may also rise. Tipranavir is always given with ritonavir, which adds to the inhibition.
What this interaction means in plain words
Diltiazem and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Mutual inhibition of CYP3A4-mediated metabolism, with additional inhibition from ritonavir.
What to do
Monitor heart rate, ECG PR interval and blood pressure, and reduce the diltiazem dose if bradycardia or hypotension occurs. Also monitor for tipranavir adverse effects such as hepatotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Diltiazem with Tipranavir?
MediHelp rates the interaction as moderate. Diltiazem and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CYP3A4 substrates and inhibitors, so combining them can raise concentrations of either one. Higher diltiazem exposure may cause bradycardia, AV block or hypotension, and tipranavir exposure may also rise. Tipranavir is always given with ritonavir, which adds to the inhibition.
How serious is the interaction between Diltiazem and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG PR interval and blood pressure, and reduce the diltiazem dose if bradycardia or hypotension occurs. Also monitor for tipranavir adverse effects such as hepatotoxicity.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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