Drug interactions
Diltiazem + Vemurafenib
Severity: Moderate
Diltiazem and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and is also a CYP3A4 inducer, so the net effect on diltiazem is uncertain. Diltiazem exposure may rise or fall, and changes in heart rate or blood pressure control are possible.
What this interaction means in plain words
Diltiazem and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein and induces CYP3A4, with opposing effects on diltiazem exposure.
What to do
Monitor heart rate, PR interval and blood pressure when starting or stopping vemurafenib. Adjust the diltiazem dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Diltiazem with Vemurafenib?
MediHelp rates the interaction as moderate. Diltiazem and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and is also a CYP3A4 inducer, so the net effect on diltiazem is uncertain. Diltiazem exposure may rise or fall, and changes in heart rate or blood pressure control are possible.
How serious is the interaction between Diltiazem and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, PR interval and blood pressure when starting or stopping vemurafenib. Adjust the diltiazem dose according to clinical response.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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