Drug interactions
Dimenhydrinate + Gabapentin enacarbil
Severity: Moderate
Dimenhydrinate and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin, which causes sedation and occasionally respiratory depression. Dimenhydrinate adds sedation, increasing drowsiness, dizziness and psychomotor impairment.
What this interaction means in plain words
Dimenhydrinate and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, particularly in older adults or those with lung disease. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Dimenhydrinate with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Dimenhydrinate and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil is converted to gabapentin, which causes sedation and occasionally respiratory depression. Dimenhydrinate adds sedation, increasing drowsiness, dizziness and psychomotor impairment.
How serious is the interaction between Dimenhydrinate and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, particularly in older adults or those with lung disease. Advise against driving until the response is known.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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