Drug interactions
Dimenhydrinate + Glycopyrronium
Severity: Moderate
Dimenhydrinate and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so using them together adds to dry mouth, blurred vision, urinary retention, constipation and tachycardia. Older patients and those with glaucoma or prostatic hypertrophy are at greater risk.
What this interaction means in plain words
Dimenhydrinate and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects at cholinergic receptors.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and confusion, and use the lowest effective doses, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Glycopyrronium?
MediHelp rates the interaction as moderate. Dimenhydrinate and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so using them together adds to dry mouth, blurred vision, urinary retention, constipation and tachycardia. Older patients and those with glaucoma or prostatic hypertrophy are at greater risk.
How serious is the interaction between Dimenhydrinate and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and confusion, and use the lowest effective doses, especially in the elderly.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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