Drug interactions
Dimenhydrinate + Maprotiline
Severity: Moderate
Dimenhydrinate and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine, a sedating anticholinergic antihistamine, and maprotiline has similar effects. Concurrent use may cause excessive drowsiness, impaired coordination and anticholinergic effects, with confusion and falls a particular concern in the elderly.
What this interaction means in plain words
Dimenhydrinate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive H1 antihistaminic sedation and additive muscarinic receptor blockade.
What to do
Avoid driving and alcohol, and use the lowest dose of dimenhydrinate for the shortest time. Monitor older adults for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Maprotiline?
MediHelp rates the interaction as moderate. Dimenhydrinate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine, a sedating anticholinergic antihistamine, and maprotiline has similar effects. Concurrent use may cause excessive drowsiness, impaired coordination and anticholinergic effects, with confusion and falls a particular concern in the elderly.
How serious is the interaction between Dimenhydrinate and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol, and use the lowest dose of dimenhydrinate for the shortest time. Monitor older adults for confusion and urinary retention.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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