Drug interactions
Dimenhydrinate + Metaxalone
Severity: Moderate
Dimenhydrinate and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and sedating antihistamines such as dimenhydrinate can add to the drowsiness caused by metaxalone. This may impair alertness, coordination and driving ability, particularly in older adults.
What this interaction means in plain words
Dimenhydrinate and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Counsel the patient about additive drowsiness and advise against driving or operating machinery until the response is known. Reduce the dose or choose a non-sedating alternative if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Metaxalone?
MediHelp rates the interaction as moderate. Dimenhydrinate and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and sedating antihistamines such as dimenhydrinate can add to the drowsiness caused by metaxalone. This may impair alertness, coordination and driving ability, particularly in older adults.
How serious is the interaction between Dimenhydrinate and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and advise against driving or operating machinery until the response is known. Reduce the dose or choose a non-sedating alternative if excessive sedation occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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