Drug interactions
Dimenhydrinate + Methohexital
Severity: Moderate
Dimenhydrinate and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anaesthetic and dimenhydrinate is sedating. Together they can increase sedation, and may deepen anaesthesia and increase respiratory and cardiovascular depression.
What this interaction means in plain words
Dimenhydrinate and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 receptor blockade.
What to do
Titrate methohexital carefully and monitor airway, ventilation and hemodynamics. Allow for slower recovery in patients recently given dimenhydrinate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Methohexital
Frequently asked questions
Can I take Dimenhydrinate with Methohexital?
MediHelp rates the interaction as moderate. Dimenhydrinate and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anaesthetic and dimenhydrinate is sedating. Together they can increase sedation, and may deepen anaesthesia and increase respiratory and cardiovascular depression.
How serious is the interaction between Dimenhydrinate and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and monitor airway, ventilation and hemodynamics. Allow for slower recovery in patients recently given dimenhydrinate.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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