Drug interactions
Dimenhydrinate + Ziprasidone
Severity: Moderate
Dimenhydrinate and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine, a sedating antihistamine, and it can add to ziprasidone-related drowsiness and psychomotor impairment. Additive anticholinergic effects may also occur.
What this interaction means in plain words
Dimenhydrinate and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects through H1 and muscarinic receptor blockade.
What to do
Counsel patients to avoid driving and alcohol while taking both. Use the lowest effective dimenhydrinate dose and monitor elderly patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Ziprasidone?
MediHelp rates the interaction as moderate. Dimenhydrinate and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine, a sedating antihistamine, and it can add to ziprasidone-related drowsiness and psychomotor impairment. Additive anticholinergic effects may also occur.
How serious is the interaction between Dimenhydrinate and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol while taking both. Use the lowest effective dimenhydrinate dose and monitor elderly patients for confusion and falls.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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