Drug interactions
Diphenhydramine + Eluxadoline
Severity: Moderate
Diphenhydramine and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Anticholinergic diphenhydramine adds to constipation and may increase the risk of serious complications.
What this interaction means in plain words
Diphenhydramine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenhydramine belongs to Respiratory; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive reduction in gastrointestinal motility from opioid receptor agonism and anticholinergic effects.
What to do
Avoid regular use of diphenhydramine with eluxadoline; if needed, monitor for constipation and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenhydramine
Other interactions of Eluxadoline
Frequently asked questions
Can I take Diphenhydramine with Eluxadoline?
MediHelp rates the interaction as moderate. Diphenhydramine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Anticholinergic diphenhydramine adds to constipation and may increase the risk of serious complications.
How serious is the interaction between Diphenhydramine and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of diphenhydramine with eluxadoline; if needed, monitor for constipation and stop eluxadoline if severe constipation develops.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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