Drug interactions
Diphenhydramine + Indacaterol-glycopyrronium
Severity: Minor
Diphenhydramine and Indacaterol-glycopyrronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine is a first-generation antihistamine with strong anticholinergic activity, and glycopyrronium is an antimuscarinic. Taken together, anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and tachycardia may be additive. Systemic exposure from inhaled glycopyrronium is low, so the effect is usually modest.
What this interaction means in plain words
Diphenhydramine and Indacaterol-glycopyrronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diphenhydramine belongs to Respiratory; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic symptoms, especially in older patients or those with glaucoma or urinary retention. Consider a less sedating, non-anticholinergic antihistamine if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as minor. Diphenhydramine and Indacaterol-glycopyrronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenhydramine is a first-generation antihistamine with strong anticholinergic activity, and glycopyrronium is an antimuscarinic. Taken together, anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and tachycardia may be additive. Systemic exposure from inhaled glycopyrronium is low, so the effect is usually modest.
How serious is the interaction between Diphenhydramine and Indacaterol-glycopyrronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially in older patients or those with glaucoma or urinary retention. Consider a less sedating, non-anticholinergic antihistamine if symptoms occur.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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