Drug interactions
Diphenhydramine + Paliperidone
Severity: Moderate
Diphenhydramine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine is a sedating antihistamine with strong anticholinergic activity, and paliperidone also causes sedation. Co-administration can lead to excessive drowsiness, confusion, constipation and urinary retention, and diphenhydramine may be used for antipsychotic extrapyramidal effects, adding to the burden.
What this interaction means in plain words
Diphenhydramine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenhydramine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects through H1 and muscarinic receptor antagonism.
What to do
Monitor for sedation, cognitive impairment and anticholinergic effects, especially in older patients. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Paliperidone?
MediHelp rates the interaction as moderate. Diphenhydramine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenhydramine is a sedating antihistamine with strong anticholinergic activity, and paliperidone also causes sedation. Co-administration can lead to excessive drowsiness, confusion, constipation and urinary retention, and diphenhydramine may be used for antipsychotic extrapyramidal effects, adding to the burden.
How serious is the interaction between Diphenhydramine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, cognitive impairment and anticholinergic effects, especially in older patients. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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