Drug interactions
Diphenoxylate + Maprotiline
Severity: Moderate
Diphenoxylate and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid-related antidiarrheal that can cause sedation, and maprotiline adds sedative and anticholinergic effects. Together they may increase drowsiness and the risk of constipation, ileus or urinary retention.
What this interaction means in plain words
Diphenoxylate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate belongs to Gastrointestinal Tract; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Use the lowest effective dose for the shortest time and monitor for sedation and abdominal distension. Avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Maprotiline?
MediHelp rates the interaction as moderate. Diphenoxylate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid-related antidiarrheal that can cause sedation, and maprotiline adds sedative and anticholinergic effects. Together they may increase drowsiness and the risk of constipation, ileus or urinary retention.
How serious is the interaction between Diphenoxylate and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time and monitor for sedation and abdominal distension. Avoid driving until the response is known.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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