Drug interactions
Diphenoxylate-atropine + Methohexital
Severity: Moderate
Diphenoxylate-atropine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic that causes marked CNS and respiratory depression. Diphenoxylate adds to these effects, which can increase anesthetic depth and the risk of hypoventilation.
What this interaction means in plain words
Diphenoxylate-atropine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from an opioid and a barbiturate.
What to do
Tell the anesthesia team about recent diphenoxylate use, and monitor ventilation and oxygen saturation. Titrate methohexital to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Diphenoxylate-atropine with Methohexital?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic that causes marked CNS and respiratory depression. Diphenoxylate adds to these effects, which can increase anesthetic depth and the risk of hypoventilation.
How serious is the interaction between Diphenoxylate-atropine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent diphenoxylate use, and monitor ventilation and oxygen saturation. Titrate methohexital to effect.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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