Drug interactions
Diphenoxylate-atropine + Oliceridine
Severity: Major
Diphenoxylate-atropine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are opioids and combining them increases sedation, respiratory depression and constipation. Atropine adds antimuscarinic effects that raise the risk of urinary retention and paralytic ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive mu-opioid agonism and antimuscarinic reduction of gut and bladder motility.
What to do
Avoid the combination if possible, and if used, monitor respiratory rate, sedation, urinary retention and bowel function. Use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Oliceridine?
MediHelp rates the interaction as major. Diphenoxylate-atropine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are opioids and combining them increases sedation, respiratory depression and constipation. Atropine adds antimuscarinic effects that raise the risk of urinary retention and paralytic ileus.
How serious is the interaction between Diphenoxylate-atropine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, and if used, monitor respiratory rate, sedation, urinary retention and bowel function. Use the lowest effective doses.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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