Drug interactions
Diphenoxylate-atropine + Pancuronium
Severity: Minor
Diphenoxylate-atropine and Pancuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pancuronium has vagolytic activity and can cause tachycardia, which may be increased by atropine. The interaction is mainly relevant if diphenoxylate-atropine is taken around the time of anesthesia, and the clinical effect is usually small.
What this interaction means in plain words
Diphenoxylate-atropine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Pancuronium belongs to Musculoskeletal.
Why it happens
Additive vagolytic and antimuscarinic effects on the heart.
What to do
No specific action is usually needed. Monitor heart rate during anesthesia if the patient has recently taken the antidiarrheal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Pancuronium
Frequently asked questions
Can I take Diphenoxylate-atropine with Pancuronium?
MediHelp rates the interaction as minor. Diphenoxylate-atropine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pancuronium has vagolytic activity and can cause tachycardia, which may be increased by atropine. The interaction is mainly relevant if diphenoxylate-atropine is taken around the time of anesthesia, and the clinical effect is usually small.
How serious is the interaction between Diphenoxylate-atropine and Pancuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is usually needed. Monitor heart rate during anesthesia if the patient has recently taken the antidiarrheal.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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