Drug interactions
Diphenoxylate-atropine + Quetiapine
Severity: Moderate
Diphenoxylate-atropine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is sedating and has anticholinergic effects through its metabolite, adding to the opioid and atropine effects of diphenoxylate-atropine. Drowsiness, constipation, urinary retention and orthostatic dizziness may increase.
What this interaction means in plain words
Diphenoxylate-atropine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for oversedation, constipation and urinary retention. Use the lowest effective dose and short duration of the antidiarrheal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Quetiapine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is sedating and has anticholinergic effects through its metabolite, adding to the opioid and atropine effects of diphenoxylate-atropine. Drowsiness, constipation, urinary retention and orthostatic dizziness may increase.
How serious is the interaction between Diphenoxylate-atropine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, constipation and urinary retention. Use the lowest effective dose and short duration of the antidiarrheal.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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