Drug interactions
Diphenoxylate-atropine + Ramelteon
Severity: Minor
Diphenoxylate-atropine and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon can cause drowsiness and dizziness, which may add to the sedative effect of diphenoxylate. The interaction is expected to be modest.
What this interaction means in plain words
Diphenoxylate-atropine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Ramelteon belongs to Central Nervous System.
Why it happens
Possible additive CNS depressant effect; no major pharmacokinetic interaction is expected.
What to do
No routine change is needed. Advise patients about additive drowsiness and caution with driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Diphenoxylate-atropine with Ramelteon?
MediHelp rates the interaction as minor. Diphenoxylate-atropine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon can cause drowsiness and dizziness, which may add to the sedative effect of diphenoxylate. The interaction is expected to be modest.
How serious is the interaction between Diphenoxylate-atropine and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients about additive drowsiness and caution with driving.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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