Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine + Mycophenolate mofetil
Severity: Moderate
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may weaken antibody responses to this inactivated combination vaccine. It carries no live-virus risk but protection may be reduced.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mycophenolate inhibits purine synthesis in T and B lymphocytes, reducing vaccine-induced immune response.
What to do
Vaccinate on schedule and ideally before immunosuppression; consider antibody testing and booster doses if the response may be inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate may weaken antibody responses to this inactivated combination vaccine. It carries no live-virus risk but protection may be reduced.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule and ideally before immunosuppression; consider antibody testing and booster doses if the response may be inadequate.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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