Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Oxaliplatin
Severity: Moderate
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin-induced immunosuppression may blunt the antibody response to the DTaP vaccine, leaving protection suboptimal. This matters most when it is given during chemotherapy.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate at least 2 weeks before chemotherapy where feasible. Revaccinate about 3 months after therapy ends if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Oxaliplatin?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin-induced immunosuppression may blunt the antibody response to the DTaP vaccine, leaving protection suboptimal. This matters most when it is given during chemotherapy.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy where feasible. Revaccinate about 3 months after therapy ends if given during treatment.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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