Drug interactions
Diphtheria and tetanus toxoids + Mycophenolate mofetil
Severity: Moderate
Diphtheria and tetanus toxoids and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may blunt antibody responses to diphtheria and tetanus toxoids, so protection may be reduced. The vaccine is non-live and safe to give.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mycophenolate inhibits purine synthesis in T and B lymphocytes, reducing vaccine-induced immune response.
What to do
Continue routine immunization without delay and consider checking antibody titers in high-risk patients. Use immune globulin for high-risk tetanus-prone wounds if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate may blunt antibody responses to diphtheria and tetanus toxoids, so protection may be reduced. The vaccine is non-live and safe to give.
How serious is the interaction between Diphtheria and tetanus toxoids and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine immunization without delay and consider checking antibody titers in high-risk patients. Use immune globulin for high-risk tetanus-prone wounds if needed.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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