Drug interactions
Diphtheria and tetanus toxoids + Sirolimus
Severity: Moderate
Diphtheria and tetanus toxoids and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may blunt the antibody response to diphtheria and tetanus toxoids, so protection may be inadequate. The toxoid vaccine is not live and carries no infection risk, so the concern is reduced efficacy only.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression by sirolimus impairs T-cell dependent antibody production after vaccination.
What to do
Give inactivated vaccines when needed, ideally before starting sirolimus. Consider checking antibody titers or giving booster doses if protection is uncertain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Sirolimus?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may blunt the antibody response to diphtheria and tetanus toxoids, so protection may be inadequate. The toxoid vaccine is not live and carries no infection risk, so the concern is reduced efficacy only.
How serious is the interaction between Diphtheria and tetanus toxoids and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated vaccines when needed, ideally before starting sirolimus. Consider checking antibody titers or giving booster doses if protection is uncertain.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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