Drug interactions
Diphtheria and tetanus toxoids + Tacrolimus
Severity: Moderate
Diphtheria and tetanus toxoids and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may reduce the antibody response to toxoid vaccines, leading to weaker protection. The vaccine is non-live and can be given safely.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent vaccine responses.
What to do
Give indicated vaccinations, preferably before transplant or when immunosuppression is lowest. Consider serologic confirmation of protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Tacrolimus?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may reduce the antibody response to toxoid vaccines, leading to weaker protection. The vaccine is non-live and can be given safely.
How serious is the interaction between Diphtheria and tetanus toxoids and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give indicated vaccinations, preferably before transplant or when immunosuppression is lowest. Consider serologic confirmation of protection.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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