Drug interactions
Dipipanone + Promethazine
Severity: Major
Dipipanone and Promethazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid analgesic, and promethazine adds sedative and hypotensive effects. The combination can cause profound drowsiness and respiratory depression, especially in opioid-naive or elderly patients.
What this interaction means in plain words
Dipipanone and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
What to do
Use reduced starting doses and monitor sedation and respiratory rate; advise against driving and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Dipipanone with Promethazine?
MediHelp rates the interaction as major. Dipipanone and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid analgesic, and promethazine adds sedative and hypotensive effects. The combination can cause profound drowsiness and respiratory depression, especially in opioid-naive or elderly patients.
How serious is the interaction between Dipipanone and Promethazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced starting doses and monitor sedation and respiratory rate; advise against driving and alcohol.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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