Drug interactions
Dipyridamole + Naldemedine
Severity: Minor
Dipyridamole and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a P-gp substrate and dipyridamole can inhibit P-gp. Higher naldemedine exposure may increase gastrointestinal effects such as abdominal pain and diarrhea. The effect is expected to be modest.
What this interaction means in plain words
Dipyridamole and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dipyridamole belongs to Cardiovascular; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of P-gp efflux by dipyridamole may increase naldemedine absorption and exposure.
What to do
No dose adjustment is routinely required; monitor for gastrointestinal adverse effects or opioid withdrawal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Dipyridamole with Naldemedine?
MediHelp rates the interaction as minor. Dipyridamole and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a P-gp substrate and dipyridamole can inhibit P-gp. Higher naldemedine exposure may increase gastrointestinal effects such as abdominal pain and diarrhea. The effect is expected to be modest.
How serious is the interaction between Dipyridamole and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required; monitor for gastrointestinal adverse effects or opioid withdrawal symptoms.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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