Drug interactions
Dipyridamole + Selexipag
Severity: Minor
Dipyridamole and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole may inhibit BCRP, which transports selexipag. This could raise selexipag exposure and cause prostacyclin-type effects such as headache, flushing, jaw pain, diarrhea and hypotension. The interaction is predicted from transporter data.
What this interaction means in plain words
Dipyridamole and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dipyridamole belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
Why it happens
BCRP inhibition by dipyridamole may increase selexipag systemic exposure.
What to do
Monitor for selexipag adverse effects such as headache, hypotension and diarrhea, and adjust the selexipag dose if tolerability is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Dipyridamole with Selexipag?
MediHelp rates the interaction as minor. Dipyridamole and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dipyridamole may inhibit BCRP, which transports selexipag. This could raise selexipag exposure and cause prostacyclin-type effects such as headache, flushing, jaw pain, diarrhea and hypotension. The interaction is predicted from transporter data.
How serious is the interaction between Dipyridamole and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects such as headache, hypotension and diarrhea, and adjust the selexipag dose if tolerability is poor.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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