Drug interactions
Gemfibrozil + Selexipag
Severity: Contraindicated
Gemfibrozil and Selexipag: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil roughly doubles selexipag exposure and greatly increases exposure to its active metabolite. This raises the risk of prostacyclin-type adverse effects such as headache, hypotension, flushing, nausea and diarrhea.
What this interaction means in plain words
Gemfibrozil and Selexipag are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemfibrozil belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
Why it happens
Gemfibrozil inhibits CYP2C8, which hydrolyzes/oxidizes selexipag and its active metabolite, reducing their clearance.
What to do
Avoid concomitant use; choose another lipid-lowering agent. Labeling contraindicates strong CYP2C8 inhibitors with selexipag.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Selexipag
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
- Deferasirox + Selexipag Moderate
Frequently asked questions
Can I take Gemfibrozil with Selexipag?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Selexipag are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil roughly doubles selexipag exposure and greatly increases exposure to its active metabolite. This raises the risk of prostacyclin-type adverse effects such as headache, hypotension, flushing, nausea and diarrhea.
How serious is the interaction between Gemfibrozil and Selexipag?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; choose another lipid-lowering agent. Labeling contraindicates strong CYP2C8 inhibitors with selexipag.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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