Drug interactions
Apalutamide + Selexipag
Severity: Moderate
Apalutamide and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag is metabolized by carboxylesterases and CYP2C8, and its active metabolite by UGT1A3 and UGT2B7. Apalutamide induces CYP enzymes and UGTs, so exposure may be reduced and pulmonary hypertension control may weaken.
What this interaction means in plain words
Apalutamide and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Selexipag belongs to Cardiovascular.
Why it happens
Apalutamide induces CYP2C8 and UGT enzymes, increasing clearance of selexipag and its active metabolite.
What to do
Monitor clinical response and symptoms of pulmonary arterial hypertension. Adjust the selexipag dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
- Deferasirox + Selexipag Moderate
Frequently asked questions
Can I take Apalutamide with Selexipag?
MediHelp rates the interaction as moderate. Apalutamide and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is metabolized by carboxylesterases and CYP2C8, and its active metabolite by UGT1A3 and UGT2B7. Apalutamide induces CYP enzymes and UGTs, so exposure may be reduced and pulmonary hypertension control may weaken.
How serious is the interaction between Apalutamide and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and symptoms of pulmonary arterial hypertension. Adjust the selexipag dose if needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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