Drug interactions
Dipyridamole + Warfarin
Severity: Moderate
Dipyridamole and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole has antiplatelet activity and can add to the bleeding tendency of warfarin. The overall increase in risk is modest and is often accepted, for example with prosthetic heart valves.
What this interaction means in plain words
Dipyridamole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of adenosine reuptake and phosphodiesterase-mediated platelet inhibition with anticoagulation.
What to do
Monitor INR and for bleeding signs. Use only when there is a clear indication for the antiplatelet effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dipyridamole with Warfarin?
MediHelp rates the interaction as moderate. Dipyridamole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole has antiplatelet activity and can add to the bleeding tendency of warfarin. The overall increase in risk is modest and is often accepted, for example with prosthetic heart valves.
How serious is the interaction between Dipyridamole and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and for bleeding signs. Use only when there is a clear indication for the antiplatelet effect.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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