Drug interactions
Disulfiram + Midazolam
Severity: Minor
Disulfiram and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram may inhibit some CYP enzymes and has been reported to modestly reduce clearance of some benzodiazepines, mainly those undergoing oxidative metabolism. Effects on midazolam are likely small but could slightly prolong sedation.
What this interaction means in plain words
Disulfiram and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of oxidative hepatic metabolism of midazolam by disulfiram.
What to do
Monitor sedation after midazolam doses in patients on disulfiram and lower subsequent doses if sedation is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Disulfiram with Midazolam?
MediHelp rates the interaction as minor. Disulfiram and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram may inhibit some CYP enzymes and has been reported to modestly reduce clearance of some benzodiazepines, mainly those undergoing oxidative metabolism. Effects on midazolam are likely small but could slightly prolong sedation.
How serious is the interaction between Disulfiram and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after midazolam doses in patients on disulfiram and lower subsequent doses if sedation is prolonged.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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