Drug interactions
Disulfiram + Piroxicam
Severity: Minor
Disulfiram and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram may inhibit CYP2C9, the main enzyme that metabolizes piroxicam, which could raise piroxicam exposure. Because piroxicam has a long half-life, higher levels may increase gastrointestinal and renal adverse effects.
What this interaction means in plain words
Disulfiram and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2C9-mediated hepatic metabolism of piroxicam by disulfiram.
What to do
No routine dose change is needed; monitor for gastrointestinal symptoms and edema, especially in older patients or with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Disulfiram with Piroxicam?
MediHelp rates the interaction as minor. Disulfiram and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram may inhibit CYP2C9, the main enzyme that metabolizes piroxicam, which could raise piroxicam exposure. Because piroxicam has a long half-life, higher levels may increase gastrointestinal and renal adverse effects.
How serious is the interaction between Disulfiram and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for gastrointestinal symptoms and edema, especially in older patients or with long-term use.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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