Drug interactions
Divalproex + Midazolam
Severity: Moderate
Divalproex and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have CNS depressant effects, so together they can cause greater sedation and, less commonly, respiratory depression. Valproate may also displace benzodiazepines from protein binding and modestly alter their effects.
What this interaction means in plain words
Divalproex and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with a possible minor pharmacokinetic contribution from protein-binding displacement.
What to do
Titrate midazolam cautiously and monitor sedation and respiratory status. Reduce the midazolam dose if excessive sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Divalproex with Midazolam?
MediHelp rates the interaction as moderate. Divalproex and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have CNS depressant effects, so together they can cause greater sedation and, less commonly, respiratory depression. Valproate may also displace benzodiazepines from protein binding and modestly alter their effects.
How serious is the interaction between Divalproex and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam cautiously and monitor sedation and respiratory status. Reduce the midazolam dose if excessive sedation develops.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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