Drug interactions
Divalproex + Rivaroxaban
Severity: Minor
Divalproex and Rivaroxaban: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Divalproex has been suggested to lower rivaroxaban levels, but the mechanism is not established and clinical data are scarce. Valproate can also impair platelet function and cause thrombocytopenia, which may add to bleeding risk.
What this interaction means in plain words
Divalproex and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established; valproate-related platelet effects may add pharmacodynamically.
What to do
No routine adjustment is needed, but monitor platelet count and watch for bleeding or thrombotic events. Review therapy if either occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Divalproex with Rivaroxaban?
MediHelp rates the interaction as minor. Divalproex and Rivaroxaban have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Divalproex has been suggested to lower rivaroxaban levels, but the mechanism is not established and clinical data are scarce. Valproate can also impair platelet function and cause thrombocytopenia, which may add to bleeding risk.
How serious is the interaction between Divalproex and Rivaroxaban?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed, but monitor platelet count and watch for bleeding or thrombotic events. Review therapy if either occurs.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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