Drug interactions
Dobutamine + Fosinopril-hydrochlorothiazide
Severity: Moderate
Dobutamine and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine's beta-2 stimulation shifts potassium into cells, and hydrochlorothiazide increases urinary potassium loss. Together they can cause clinically relevant hypokalemia, raising arrhythmia risk in cardiac patients.
What this interaction means in plain words
Dobutamine and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive lowering of serum potassium through beta-2 mediated intracellular shift and thiazide renal potassium wasting.
What to do
Monitor serum potassium during dobutamine infusion and replace potassium as needed. Consider telemetry in patients with arrhythmia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dobutamine and Fosinopril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dobutamine and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine's beta-2 stimulation shifts potassium into cells, and hydrochlorothiazide increases urinary potassium loss. Together they can cause clinically relevant hypokalemia, raising arrhythmia risk in cardiac patients.
How serious is the interaction between Dobutamine and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during dobutamine infusion and replace potassium as needed. Consider telemetry in patients with arrhythmia risk.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
