Drug interactions
Dobutamine + Hydrochlorothiazide-losartan
Severity: Moderate
Dobutamine and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine stimulates beta-2 receptors and drives potassium into cells, while hydrochlorothiazide promotes renal potassium loss. Together they can lower serum potassium more than either alone, which may provoke arrhythmias in susceptible patients.
What this interaction means in plain words
Dobutamine and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive hypokalemia through beta-2-mediated intracellular potassium shift plus thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium and ECG during dobutamine infusion in patients taking the thiazide. Replace potassium as needed, especially in patients with heart disease or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Dobutamine and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine stimulates beta-2 receptors and drives potassium into cells, while hydrochlorothiazide promotes renal potassium loss. Together they can lower serum potassium more than either alone, which may provoke arrhythmias in susceptible patients.
How serious is the interaction between Dobutamine and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dobutamine infusion in patients taking the thiazide. Replace potassium as needed, especially in patients with heart disease or on other QT-prolonging drugs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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