Drug interactions
Dobutamine + Maprotiline
Severity: Moderate
Dobutamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, blocks norepinephrine reuptake and may enhance cardiovascular responses to sympathomimetics. With dobutamine the effect is usually modest but tachycardia, hypertension and arrhythmias can occur.
What this interaction means in plain words
Dobutamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
Why it happens
Inhibition of norepinephrine reuptake and adrenergic receptor sensitization potentiate catecholamine effects.
What to do
Monitor ECG, heart rate and blood pressure during dobutamine infusion and start at a low dose, titrating cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dobutamine and Maprotiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dobutamine
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Dobutamine with Maprotiline?
MediHelp rates the interaction as moderate. Dobutamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline, a tetracyclic antidepressant, blocks norepinephrine reuptake and may enhance cardiovascular responses to sympathomimetics. With dobutamine the effect is usually modest but tachycardia, hypertension and arrhythmias can occur.
How serious is the interaction between Dobutamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure during dobutamine infusion and start at a low dose, titrating cautiously.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
