Drug interactions
Dobutamine + Nebivolol
Severity: Moderate
Dobutamine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol blocks beta-1 receptors and can blunt the inotropic and chronotropic response to dobutamine. This may reduce the efficacy of dobutamine, for example in stress echocardiography or cardiogenic shock.
What this interaction means in plain words
Dobutamine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-1 adrenergic receptors.
What to do
Consider holding nebivolol before dobutamine stress testing, or expect higher dobutamine doses to be needed. Monitor hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Nebivolol?
MediHelp rates the interaction as moderate. Dobutamine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol blocks beta-1 receptors and can blunt the inotropic and chronotropic response to dobutamine. This may reduce the efficacy of dobutamine, for example in stress echocardiography or cardiogenic shock.
How serious is the interaction between Dobutamine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding nebivolol before dobutamine stress testing, or expect higher dobutamine doses to be needed. Monitor hemodynamic response.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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