Drug interactions
Dobutamine + Procarbazine
Severity: Major
Dobutamine and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitory activity, which can potentiate sympathomimetic amines and trigger hypertensive episodes. Dobutamine is a catecholamine metabolized in part by COMT and MAO, so exaggerated pressor and cardiac responses are possible.
What this interaction means in plain words
Dobutamine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine reduces catecholamine breakdown and potentiates sympathomimetic effects.
What to do
Avoid if possible; if dobutamine is needed, begin at a very low dose with continuous blood pressure and ECG monitoring and titrate slowly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dobutamine
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Dobutamine with Procarbazine?
MediHelp rates the interaction as major. Dobutamine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has weak monoamine oxidase inhibitory activity, which can potentiate sympathomimetic amines and trigger hypertensive episodes. Dobutamine is a catecholamine metabolized in part by COMT and MAO, so exaggerated pressor and cardiac responses are possible.
How serious is the interaction between Dobutamine and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if dobutamine is needed, begin at a very low dose with continuous blood pressure and ECG monitoring and titrate slowly.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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