Drug interactions
Dobutamine + Tolcapone
Severity: Moderate
Dobutamine and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is partly inactivated by catechol-O-methyltransferase (COMT). Tolcapone inhibits COMT, which may prolong and enhance dobutamine's effects and lead to tachycardia, arrhythmia or blood pressure changes.
What this interaction means in plain words
Dobutamine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Tolcapone belongs to Central Nervous System.
Why it happens
Tolcapone inhibits COMT, reducing metabolic clearance of the catecholamine dobutamine.
What to do
Monitor heart rate, rhythm and blood pressure closely during dobutamine infusion in patients on tolcapone. Use lower starting infusion rates and titrate cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Dobutamine with Tolcapone?
MediHelp rates the interaction as moderate. Dobutamine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine is partly inactivated by catechol-O-methyltransferase (COMT). Tolcapone inhibits COMT, which may prolong and enhance dobutamine's effects and lead to tachycardia, arrhythmia or blood pressure changes.
How serious is the interaction between Dobutamine and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure closely during dobutamine infusion in patients on tolcapone. Use lower starting infusion rates and titrate cautiously.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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