Drug interactions
Docetaxel + Duvelisib
Severity: Moderate
Docetaxel and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and increases exposure to sensitive CYP3A4 substrates. Higher docetaxel levels may worsen myelosuppression and other toxicity.
What this interaction means in plain words
Docetaxel and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing docetaxel clearance.
What to do
Consider reducing the docetaxel dose and monitor blood counts and signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Docetaxel with Duvelisib?
MediHelp rates the interaction as moderate. Docetaxel and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and increases exposure to sensitive CYP3A4 substrates. Higher docetaxel levels may worsen myelosuppression and other toxicity.
How serious is the interaction between Docetaxel and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the docetaxel dose and monitor blood counts and signs of toxicity.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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