Drug interactions
Docetaxel + Isavuconazonium
Severity: Moderate
Docetaxel and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active drug, is a moderate CYP3A4 inhibitor and may raise docetaxel exposure, increasing the risk of docetaxel toxicity. Docetaxel is not a meaningful inhibitor of CYP3A4, so the effect on isavuconazole is negligible.
What this interaction means in plain words
Docetaxel and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4 metabolism of docetaxel.
What to do
Monitor blood counts and docetaxel toxicity closely and consider reducing the docetaxel dose, or choose a non-azole antifungal where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Docetaxel with Isavuconazonium?
MediHelp rates the interaction as moderate. Docetaxel and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active drug, is a moderate CYP3A4 inhibitor and may raise docetaxel exposure, increasing the risk of docetaxel toxicity. Docetaxel is not a meaningful inhibitor of CYP3A4, so the effect on isavuconazole is negligible.
How serious is the interaction between Docetaxel and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and docetaxel toxicity closely and consider reducing the docetaxel dose, or choose a non-azole antifungal where appropriate.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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