Drug interactions
Docetaxel + Lapatinib
Severity: Moderate
Docetaxel and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein and also CYP3A4, so it may raise docetaxel exposure. Higher docetaxel levels could worsen neutropenia, neuropathy and other dose-related toxicities.
What this interaction means in plain words
Docetaxel and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits P-glycoprotein efflux and CYP3A4, potentially reducing docetaxel elimination.
What to do
Monitor blood counts and signs of docetaxel toxicity such as neutropenia, neuropathy and fluid retention. Consider docetaxel dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Docetaxel with Lapatinib?
MediHelp rates the interaction as moderate. Docetaxel and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein and also CYP3A4, so it may raise docetaxel exposure. Higher docetaxel levels could worsen neutropenia, neuropathy and other dose-related toxicities.
How serious is the interaction between Docetaxel and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of docetaxel toxicity such as neutropenia, neuropathy and fluid retention. Consider docetaxel dose reduction if toxicity emerges.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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