Drug interactions
Docetaxel + Mifepristone
Severity: Major
Docetaxel and Mifepristone: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase docetaxel exposure, raising the risk of neutropenia, neuropathy, fluid retention and other toxicities. Risk is most relevant with chronic mifepristone use rather than single doses for pregnancy termination.
What this interaction means in plain words
Docetaxel and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Docetaxel belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone decreases docetaxel clearance.
What to do
With chronic mifepristone, monitor closely for docetaxel toxicity and consider reducing the docetaxel dose; avoid the combination where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Mifepristone?
MediHelp rates the interaction as major. Docetaxel and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and may increase docetaxel exposure, raising the risk of neutropenia, neuropathy, fluid retention and other toxicities. Risk is most relevant with chronic mifepristone use rather than single doses for pregnancy termination.
How serious is the interaction between Docetaxel and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With chronic mifepristone, monitor closely for docetaxel toxicity and consider reducing the docetaxel dose; avoid the combination where possible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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