Drug interactions
Docetaxel + Nicardipine
Severity: Moderate
Docetaxel and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit P-glycoprotein and CYP3A4 and could increase docetaxel exposure. This could increase neutropenia and other toxicities, though clinical data are limited.
What this interaction means in plain words
Docetaxel and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of P-glycoprotein efflux and CYP3A4 metabolism of docetaxel by nicardipine.
What to do
Monitor neutrophil counts and signs of docetaxel toxicity. Consider an alternative antihypertensive if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Nicardipine?
MediHelp rates the interaction as moderate. Docetaxel and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may inhibit P-glycoprotein and CYP3A4 and could increase docetaxel exposure. This could increase neutropenia and other toxicities, though clinical data are limited.
How serious is the interaction between Docetaxel and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of docetaxel toxicity. Consider an alternative antihypertensive if toxicity emerges.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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