Drug interactions
Docetaxel + Rifapentine
Severity: Moderate
Docetaxel and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is a CYP3A4 inducer and may speed up the metabolism of docetaxel, a CYP3A4 substrate. Exposure to docetaxel may fall, which could reduce its antitumor effect.
What this interaction means in plain words
Docetaxel and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces hepatic and intestinal CYP3A4, increasing docetaxel clearance.
What to do
Prefer an alternative antimycobacterial agent without strong enzyme induction where possible. If the combination is unavoidable, monitor for reduced docetaxel efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Docetaxel with Rifapentine?
MediHelp rates the interaction as moderate. Docetaxel and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is a CYP3A4 inducer and may speed up the metabolism of docetaxel, a CYP3A4 substrate. Exposure to docetaxel may fall, which could reduce its antitumor effect.
How serious is the interaction between Docetaxel and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antimycobacterial agent without strong enzyme induction where possible. If the combination is unavoidable, monitor for reduced docetaxel efficacy.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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